2026 Drug Cost Guide: Keytruda, Wegovy, Mounjaro, Zepbound, Opdivo & Imfinzi Prices

Updated U.S. drug cost data (Keytruda, Wegovy, Mounjaro, Zepbound) — Insurance, savings & 2026 trends.

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Ozempic Cost in the USA 2025: Monthly Price, Insurance Coverage, and Cheaper Alternatives - 2026 Drug Cost Analysis

Ozempic Cost in the USA 2025: Monthly Price, Insurance Coverage, and Cheaper Alternatives

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Ozempic continues to be one of the most prescribed GLP-1 medications in the U.S. for weight management and type 2 diabetes. In 2025, the monthly cost of Ozempic without insurance can exceed $1,000, but with insurance, patients may pay as little as $25–$100 depending on their copay and formulary status. Alternatives such as Wegovy, Rybelsus, and generic GLP-1 options are increasingly in demand. This guide provides the latest 2025 pricing, insurance coverage details, and cheaper alternatives for patients seeking affordable access.

How Much Does Semaglutide Cost in the US Without Insurance (2025) - 2026 Drug Cost Analysis

How Much Does Semaglutide Cost in the US Without Insurance (2025)

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In 2025, the cost of semaglutide (Ozempic, Wegovy, Rybelsus) in the United States remains one of the biggest challenges for patients without insurance. On average, the monthly out-of-pocket price ranges between $1,000 and $1,400, depending on dosage and brand. Even though semaglutide is highly effective for type 2 diabetes and weight loss, its high retail cost makes it inaccessible for many people. However, patients can lower their expenses through manufacturer savings programs, GoodRx coupons, and pharmacy discount cards, which may reduce the Wegovy cash price or Ozempic monthly cost to as little as $499. Alternatives such as Mounjaro (tirzepatide) or compounded semaglutide also exist, but safety and availability should always be considered. This guide explores real patient costs, discount programs, insurance coverage updates, and the future of GLP-1 drug pricing, helping you understand exactly what to expect if you’re paying for semaglutide out of pocket in 2025.

Drug Price FAQs: Keytruda, Wegovy, Mounjaro & More

The average cost of Keytruda without insurance in 2026 is around $10,000 to $13,000 per dose. With insurance, out-of-pocket expenses can be as low as $100 depending on the coverage.

Experts expect Zepbound’s price to drop by 10–15% in 2026 as competition and insurance coverage expand. Savings cards and manufacturer programs are also expected to continue.

Wegovy costs between $25 and $150 per month with most insurance plans in the U.S. Without insurance, the price is around $1,350 monthly.

Top Drug Comparisons 2026: Keytruda, Mounjaro, Wegovy & Zepbound

Keytruda vs Opdivo

Compare the 2026 cost, effectiveness, and insurance coverage of both cancer treatments.

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Wegovy vs Zepbound

Find out which weight-loss drug offers the best value and results in 2026.

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Mounjaro Savings 2026

Learn how to get the best savings and discounts for Mounjaro through insurance and cards.

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2026 UPDATE
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2026 Drug Cost Guide
Keytruda • Wegovy • Mounjaro • Zepbound
Insurance Coverage Savings Tips Price Trends
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Average Savings: 65%
Trending Drug Prices 2026
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Keytruda
$12,500/month
+5.2%
⚖️
Wegovy
$1,349/month
-2.1%
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Mounjaro
$1,023/month
+3.8%
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Zepbound
$1,059/month
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