2026 Drug Cost Guide: Keytruda, Wegovy, Mounjaro, Zepbound, Opdivo & Imfinzi Prices

Updated U.S. drug cost data (Keytruda, Wegovy, Mounjaro, Zepbound) — Insurance, savings & 2026 trends.

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How Much Does Keytruda Cost with Insurance in the U.S.? - 2026 Drug Cost Analysis

How Much Does Keytruda Cost with Insurance in the U.S.?

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In 2026, most patients pay between $300 and $3,000 per month depending on their plan, deductible, and location. This complete guide breaks down Keytruda prices with and without insurance, Medicare coverage, patient assistance programs, and expert insights to help Americans save on cancer treatment costs.

How Much Does Keytruda Cost in the US in 2025? - 2026 Drug Cost Analysis

How Much Does Keytruda Cost in the US in 2025?

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How Much Does Keytruda Cost in the US in 2025? Price per Dose, Monthly Cost, and Insurance Coverage Updated: October 1, 2025 Keytruda (pembrolizumab) remains one of the most prescribed immunotherapy treatments for cancers such as melanoma, non-small cell lung cancer, and head and neck cancers. But for patients and families, the most pressing question is often: “How much does Keytruda cost in the US in 2025?” In this guide, we break down the latest Keytruda prices per dose, monthly treatment costs, and annual expenses. We also compare prices from leading sources like GoodRx , Drugs.com , and SingleCare to help you understand the current landscape. Beyond raw prices, we explain how insurance coverage, Medicare, and manufacturer assistance programs can dramatically reduce out-of-pocket costs. If you or a loved one are exploring treatment with Keytruda, this resource provides the most up-to-date 2025 information to help you plan financially and discuss options with your healthcare provider.

Keytruda Cost in 2025: Real Monthly Price, Insurance Coverage & Patient Tips - 2026 Drug Cost Analysis

Keytruda Cost in 2025: Real Monthly Price, Insurance Coverage & Patient Tips

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Keytruda (pembrolizumab) is one of the most widely prescribed immunotherapy drugs for cancer — but its high cost often leaves patients wondering how much they will actually pay. In 2025, the average list price for a single Keytruda infusion is around $11,000–$12,000, with annual costs exceeding $190,000 before insurance. Fortunately, Medicare, Medicaid, and private insurers cover most of these expenses, and copay assistance programs can reduce patient costs to as little as $25 per infusion. This guide explains the real monthly price of Keytruda in 2025, how insurance coverage works, and practical tips patients can use to lower out-of-pocket expenses.

How Much Does Keytruda Cost Per Month? - 2026 Drug Cost Analysis

How Much Does Keytruda Cost Per Month?

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Keytruda (pembrolizumab) has transformed cancer treatment, but its price tag remains one of the highest in oncology. In 2025, the average monthly cost of Keytruda in the United States is estimated at $15,000 to $16,000, depending on the dosing schedule. While list prices are staggering, most patients do not pay this full amount thanks to insurance coverage, Medicare benefits, and financial assistance programs. Still, questions like “How much does Keytruda cost per month?” and “Why is Keytruda so expensive?” are critical for patients, caregivers, and policymakers navigating the realities of modern cancer care.

Drug Price FAQs: Keytruda, Wegovy, Mounjaro & More

The average cost of Keytruda without insurance in 2026 is around $10,000 to $13,000 per dose. With insurance, out-of-pocket expenses can be as low as $100 depending on the coverage.

Experts expect Zepbound’s price to drop by 10–15% in 2026 as competition and insurance coverage expand. Savings cards and manufacturer programs are also expected to continue.

Wegovy costs between $25 and $150 per month with most insurance plans in the U.S. Without insurance, the price is around $1,350 monthly.

Top Drug Comparisons 2026: Keytruda, Mounjaro, Wegovy & Zepbound

Keytruda vs Opdivo

Compare the 2026 cost, effectiveness, and insurance coverage of both cancer treatments.

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Wegovy vs Zepbound

Find out which weight-loss drug offers the best value and results in 2026.

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Mounjaro Savings 2026

Learn how to get the best savings and discounts for Mounjaro through insurance and cards.

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2026 UPDATE
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2026 Drug Cost Guide
Keytruda • Wegovy • Mounjaro • Zepbound
Insurance Coverage Savings Tips Price Trends
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Average Savings: 65%
Trending Drug Prices 2026
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Keytruda
$12,500/month
+5.2%
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Wegovy
$1,349/month
-2.1%
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Mounjaro
$1,023/month
+3.8%
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Zepbound
$1,059/month
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Keytruda Cost in the USA: How Much Does Pembrolizumab Really Cost in 2025?
Keytruda Cost in the USA: How Much Does Pembrolizumab Really Cost in 2025?
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How Much Does Keytruda Cost Per Month?
How Much Does Keytruda Cost Per Month?
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Keytruda Price Per Dose vs. Per Year — Full Breakdown (2025)
Keytruda Price Per Dose vs. Per Year — Full Breakdown (2025)
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