2026 Drug Cost Guide: Keytruda, Wegovy, Mounjaro, Zepbound, Opdivo & Imfinzi Prices

Updated U.S. drug cost data (Keytruda, Wegovy, Mounjaro, Zepbound) — Insurance, savings & 2026 trends.

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How Much Does Keytruda Cost with Insurance in the U.S.? - 2026 Drug Cost Analysis

How Much Does Keytruda Cost with Insurance in the U.S.?

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In 2026, most patients pay between $300 and $3,000 per month depending on their plan, deductible, and location. This complete guide breaks down Keytruda prices with and without insurance, Medicare coverage, patient assistance programs, and expert insights to help Americans save on cancer treatment costs.

How Much Does Keytruda Cost Per Month? - 2026 Drug Cost Analysis

How Much Does Keytruda Cost Per Month?

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Keytruda (pembrolizumab) has transformed cancer treatment, but its price tag remains one of the highest in oncology. In 2025, the average monthly cost of Keytruda in the United States is estimated at $15,000 to $16,000, depending on the dosing schedule. While list prices are staggering, most patients do not pay this full amount thanks to insurance coverage, Medicare benefits, and financial assistance programs. Still, questions like “How much does Keytruda cost per month?” and “Why is Keytruda so expensive?” are critical for patients, caregivers, and policymakers navigating the realities of modern cancer care.

Drug Price FAQs: Keytruda, Wegovy, Mounjaro & More

The average cost of Keytruda without insurance in 2026 is around $10,000 to $13,000 per dose. With insurance, out-of-pocket expenses can be as low as $100 depending on the coverage.

Experts expect Zepbound’s price to drop by 10–15% in 2026 as competition and insurance coverage expand. Savings cards and manufacturer programs are also expected to continue.

Wegovy costs between $25 and $150 per month with most insurance plans in the U.S. Without insurance, the price is around $1,350 monthly.

Top Drug Comparisons 2026: Keytruda, Mounjaro, Wegovy & Zepbound

Keytruda vs Opdivo

Compare the 2026 cost, effectiveness, and insurance coverage of both cancer treatments.

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Wegovy vs Zepbound

Find out which weight-loss drug offers the best value and results in 2026.

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Mounjaro Savings 2026

Learn how to get the best savings and discounts for Mounjaro through insurance and cards.

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2026 UPDATE
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2026 Drug Cost Guide
Keytruda • Wegovy • Mounjaro • Zepbound
Insurance Coverage Savings Tips Price Trends
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Average Savings: 65%
Trending Drug Prices 2026
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Keytruda
$12,500/month
+5.2%
⚖️
Wegovy
$1,349/month
-2.1%
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Mounjaro
$1,023/month
+3.8%
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Zepbound
$1,059/month
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